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IB-, a new anti-inflammatory nuclear protein induced by lipopolysaccharide, is a negative regulator for nuclear factor-B

Department of Molecular and Cellular Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, tmuta{at}mailserver.med.kyushu-u.ac.jp, 'Host and Defense', PRESTO, Japan Science and Technology Corporation (JST), Japan

Soh Yamazaki

Department of Molecular and Cellular Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Akiko Eto

Department of Molecular and Cellular Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Masaiwa Motoyama

Department of Molecular and Cellular Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Koichiro Takeshige

Department of Molecular and Cellular Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Activation of nuclear factor- B (NF- B), a prominent cellular response to bacterial endotoxin or other microbial products, must be strictly regulated because excessive activation leads to overproduction of cytotoxic cytokines that culminates in septic shock. During screening for genes up-regulated upon inflammation, we identified a new member of the IB family proteins with the ankyrin-repeats. This protein, designated I B- , is hardly detectable in resting cells, but is strongly induced upon stimulation by lipopolysaccharide, which stimulates cells through the Toll-like receptor 4. Interleukin-1ß stimulation also results in the strong induction of IB-, but tumor necrosis factor- does not. In contrast to IB- or I B-ß , IB- localizes in the nucleus, where it inhibits NF-B activity. NF- B activity is essential for the induction of IB-, but is not sufficient. Thus, this protein is a new anti-inflammatory protein, which is specifically induced upon inflammation to regulate NF-B activity.

Journal of Endotoxin Research, Vol. 9, No. 3, 187-191 (2003)
DOI: 10.1177/09680519030090030801


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