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Modulating macrophage function with IgG immune complexes

Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA

Jeffrey S. Gerber

Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA

David M. Mosser

Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA, dm268{at}umail.umd.edu

Macrophages respond to bacterial products by releasing a large array of inflammatory mediators. We demonstrate that, in the presence of IgG immune complexes, macrophages produce high levels of IL-10 and virtually no IL-12, when they are exposed to bacterial products. The production of IL-10 by these cells can dampen innate inflammatory responses to microbial products, such as LPS. This alteration in macrophage cytokine production can also influence an adaptive immune response, preferentially inducing Th2-type immunity. Thus, immune complexes change the physiology of activated macrophages, converting them to anti-inflammatory cells that induce Th2-like immune responses. We have termed these cells type II activated macrophages.

Journal of Endotoxin Research, Vol. 8, No. 6, 477-481 (2002)
DOI: 10.1177/09680519020080060501


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