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Journal of Endotoxin Research
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The clinical relevance of endotoxin in human sepsis: a critical analysis

Steven M. Opal

Infectious Disease Division, Brown Medical School, Memorial Hospital of Rhode Island, Pawtucket, Rhode Island, USA, Steven_Opal{at}brown.edu

Correlations between circulating endotoxin levels from the blood of septic patients with clinical outcome measures have proven to be rather difficult. The clinical impact of endotoxin in septic patients depends upon the kinetics of LPS release, the concentration of LPS binding proteins, the cellular responsiveness to endotoxin, and numerous other immunogenetic, microbiological and physiological variables. Failure to account for these variables adequately has limited the clinical utility of endotoxin measurement. Several clinical studies have associated high levels of LPS with an excess risk of morbidity and mortality in sepsis that is largely independent of the nature of the micro-organism responsible for the septic episode.

Journal of Endotoxin Research, Vol. 8, No. 6, 473-476 (2002)
DOI: 10.1177/09680519020080060401
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?