Journal of Endotoxin Research

 

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Journal of Endotoxin Research, Vol. 8, No. 5, 365-369 (2002)
DOI: 10.1177/09680519020080051001

Requirement of TNF and TNF receptor type 2 for LPS-induced protection from lethal septic peritonitis

Bernd Echtenacher

Institute for Pathology and Tumor Immunology, University of Regensburg, Regensburg, Germany

Daniela N. Männel

Institute for Pathology and Tumor Immunology, University of Regensburg, Regensburg, Germany, daniela.maennel{at}klinik.uni-regensburg.de

Pretreatment of mice with low quantities of LPS induces endotoxin tolerance characterized by enhanced resistance to lethal doses of LPS and to a number of infectious challenges. M ice subjected to cecal ligation and puncture (CLP) survived the ensuing septic peritonitis significantly better when they had been pretreated with LPS. This LPS-induced protection was dependent on endogenous TNF production capacity since LPS pretreatment did not protect TNF-deficient mice from death after CLP. W hile mice deficient in the TNF receptor type 2 (p75TNFR) were as sensitive to CLP-induced mortality as control mice, LPS pretreatment could not reduce mortality in p75TNFR-deficient mice after CLP. Therefore, activation of the TNF receptor type 2 by endogenous TNF constitutes an important interaction for the development of LPS-induced resistance to bacterial infection.


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