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Journal of Endotoxin Research
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Differential clearance and induction of host responses by various administered or released lipopolysaccharides

Ryoichi Hasunuma

Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan

Hiroyuki Morita

Seikagaku Corp., Tokyo, Japan

Shigenori Tanaka

Seikagaku Corp., Tokyo, Japan

Roland Ryll

Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan

Marina A. Freudenberg

Max-Planck-Institute for Immunobiology, Freiburg/Breisgau, Germany

Chris Galanos

Max-Planck-Institute for Immunobiology, Freiburg/Breisgau, Germany

Yoshio Kumazawa

Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan, kumazawa{at}jet.sci.kitasato-u.ac.jp

The clearance and activity of different types of lipopolysaccharide (LPS) released during infection with Gram-negative bacteria were investigated. When highly purified preparations differing in their specific endotoxin activity were administered intravenously to mice, the clearance of rough (R)-form LPS preparations from Salmonella minnesota and Escherichia coli was much faster than that of a smooth (S)-form LPS preparation from Salmonella abortus equi, but slower than that of lipooligosaccharides (LOS) preparations from Bordetella pertussis and Helicobacter pylori. After intraperitoneal infection with 107 and 108 CFU E. coli O111:B4, relatively high levels of LPS were detected dose-dependently in the plasma of infected mice and persisted for a long time. In addition, plasma sCD14 levels in infected mice were higher than in LPS-administered mice. These results indicate that continuously higher levels of plasma LPS followed by stronger host responses occur during infection and suggest that these differences between LPS-administered and infected mice should be taken into consideration when analyzing host responses induced by LPS.

Journal of Endotoxin Research, Vol. 7, No. 6, 421-429 (2001)
DOI: 10.1177/09680519010070060501
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