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MD-2 binds to bacterial lipopolysaccharide

Department of Pathology and Medicine, Department of Veterans Affairs Medical Center, University of California San Diego, San Diego, California, USA

T.N. Kirkland

Department of Pathology and Medicine, Department of Veterans Affairs Medical Center, University of California San Diego, San Diego, California, USA. tkirkland{at}ucsd.edu

K. Soldau

Department of Immunology, The Scripps Research Institute, La Jolla, California, USA

P.S. Tobias

Department of Immunology, The Scripps Research Institute, La Jolla, California, USA

Many LPS binding proteins have been described, but the exact nature of the LPS receptors that signal cells remains unclear. MD-2 is a molecule that is found in association with Toll-like receptor 4, which has been shown to be a receptor for LPS. We have produced human MD-2 in baculovirus and tested it for LPS binding. MD-2 binds the lipid A region of LPS without the need for LPS binding protein. These data suggest that MD-2 may be binding LPS as part of the TLR4 receptor complex.

Journal of Endotoxin Research, Vol. 6, No. 6, 489-491 (2000)
DOI: 10.1177/09680519000060060201


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