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Journal of Endotoxin Research
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A horseshoe crab receptor structurally related to Drosophila Toll

Kei-ichiro Inamori

Department of Molecular Biology, Kyushu University, Fukuota, Japan

Kumiko Koori

Department of Biology, Kyushu University, Fukuoka, Japan

Chiemi Mishima

Department of Biology, Kyushu University, Fukuoka, Japan

Tatsushi Muta

Department of Molecular and Cellular Biochemistry, Kyushu University, Fukuoka, Japan

Shun-ichiro Kawabata

Department of Molecular Biology, Kyushu University, Fukuota, Japan, Department of Biology, Kyushu University, Fukuoka, Japan, skawascb{at}mbox.nc.kyushu-u.ac.jp

Innate immunity against microbial pathogens relies on the pattern recognition of cell wall components on invading microbes. Recent evidence has shown that a mammalian Toll-like receptor (TLR) is activated by bacterial lipopolysaccharides (LPS). The innate immunity in invertebrates is also triggered by LPS, as seen in the hemolymph coagulation in horseshoe crab. We report the cloning of a TLR from the Japanese horseshoe crab Tachypleus tridentatus. A cDNA coding for Tachypleus Toll was isolated from a hemocyte cDNA library and the open reading frame codes for a proprotein including a signal sequence. Like Drosophila Toll, Tachypleus Toll is a type I transmembrane protein with an extracellular domain consisting of two leucine-rich repeats flanked by two cystein-rich clusters and a cytoplasmic domain exhibiting striking similarity with the cytoplasmic domain of interleukin-1 receptor. Tachypleus Toll is most similar to Drosophila Toll in the domain architecture and the overall length.

Journal of Endotoxin Research, Vol. 6, No. 5, 397-399 (2000)
DOI: 10.1177/09680519000060051201
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