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Journal of Endotoxin Research
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The role of Helicobacter pylori LPS in the pathogenesis of H. pylori-related gastropathy

E. Jirillo

Department of Immunology, University of Bari, Bari, Italy, Jirillo{at}uniba.it

S. Pece

Department of Immunology, University of Bari, Bari, Italy

N.M. Pellegrino

Department of Immunology, University of Bari, Bari, Italy

A. Di Leo

Scientific Institute for Gastroenterological Diseases, Castellana Grotte, Bari, Italy

F. Russo

Scientific Institute for Gastroenterological Diseases, Castellana Grotte, Bari, Italy

M. Linsalata

Scientific Institute for Gastroenterological Diseases, Castellana Grotte, Bari, Italy

C. Messa

Scientific Institute for Gastroenterological Diseases, Castellana Grotte, Bari, Italy

L. Amati

Scientific Institute for Gastroenterological Diseases, Castellana Grotte, Bari, Italy

L. Caradonna

Scientific Institute for Gastroenterological Diseases, Castellana Grotte, Bari, Italy

A.P. Moran

Department of Microbiology, National University of Ireland Galway, Galway, Ireland

D. Caccavo

Department of Immunology, University of Bari, Bari, Italy

Helicobacter pylori strains and/or their lipopolysaccharides (LPS) represent the trigger of different regional and systemic immune responses in the course of H. pylori-related gastropathy as indicated by the following: (i) in patients with chronic gastritis (CG) or duodenal ulcer (DU), eradication of H. pylori leads to a dramatic decrease of gastric mucosal content of various cytokines such as interleukin-1ß and transforming growth factor-ß1; (ii) gastric epithelial cells are activated by H. pylori organisms through tyrosine phosphorylation signaling events but H. pylori LPSs do not affect this signal transduction pathway; and (iii) in sera from patients with CG and DU, besides antibodies to S-form LPS, humoral IgG and IgA response against R-form LPS has been also detected. On the other hand, antibodies against synthetic polymeric Lewisx were found in a few patients with CG and in no patients with DU.

Journal of Endotoxin Research, Vol. 5, No. 4, 222-226 (1999)
DOI: 10.1177/09680519990050041101
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