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Journal of Endotoxin Research
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Identification of CD18 as a novel Taxol binding/signaling protein in murine macrophage membranes

Stefanie N. Vogel

Department of Microbiology and Immunology, USUHS, Bethesda, Maryland, USA

Nayantara Bhat

Department of Microbiology and Immunology, USUHS, Bethesda, Maryland, USA

Joan M. Carboni

Oncology Drug Discovery, Bristol-Myers Squibb, Princeton, New Jersey, USA

Tanya N. Mayadas

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA

Jorge Blanco

Department of Microbiology and Immunology, USUHS, Bethesda, Maryland, USA

Pin-Yu Perera

Department of Microbiology and Immunology, USUHS, Bethesda, Maryland, USA

Douglas T. Golenbock

The Maxwell Finland Laboratory for Infectious Diseases, Boston Univ. School of Medicine, Boston, Massachusetts, USA

The anti-tumor agent, Taxol, is a potent LPS mimetic in murine macrophages, an activity that is dissociable from its well-characterized anti-mitotic activity which is mediated by microtubule hyperstabilization. A photoactivatable Taxol analog was used to identify components of a putative, shared LPS signaling apparatus in murine macrophage membranes. We report here that CD18, the ß chain of the ß2-integrin, Mac-1, represents a major Taxol binding protein in murine macrophages.

Journal of Endotoxin Research, Vol. 5, No. 3, 170-173 (1999)
DOI: 10.1177/09680519990050030101
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