Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Endotoxin Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Valvano, M. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Valvano, M. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biosynthesis and genetics of ADP-heptose

Miguel A. Valvano

Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada

Glycero-manno-heptose is a common component in the lipopolysaccharide (LPS) of many Gram-negative bacteria. Mutants deficient in the synthesis of glycero-manno-heptose are highly sensitive to hydrophobic compounds, and display reduced virulence, making these genes and their products potential targets for developing novel antimicrobials. To date, the biosynthesis of the heptosyl precursors for the inner core oligosaccharide of the LPS molecule is not completely characterized. In this work, the genes and enzyme functions involved in the various steps of the biosynthesis of ADP-L-glycero-D-manno-heptose are discussed, especially those involved in the intermediate steps.

Journal of Endotoxin Research, Vol. 5, No. 1-2, 90-95 (1999)
DOI: 10.1177/09680519990050010901
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Bacteriol.Home page
F. McArthur, C. E. Andersson, S. Loutet, S. L. Mowbray, and M. A. Valvano
Functional Analysis of the glycero-manno-Heptose 7-Phosphate Kinase Domain from the Bifunctional HldE Protein, Which Is Involved in ADP-L-glycero-D-manno-Heptose Biosynthesis
J. Bacteriol., August 1, 2005; 187(15): 5292 - 5300.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
M. A. Valvano, P. Messner, and P. Kosma
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides
Microbiology, July 1, 2002; 148(7): 1979 - 1989.
[Full Text] [PDF]

Home page
 J. Bacteriol.Home page
B. Kneidinger, C. Marolda, M. Graninger, A. Zamyatina, F. McArthur, P. Kosma, M. A. Valvano, and P. Messner
Biosynthesis Pathway of ADP-L-glycero-{beta}-D-manno-Heptose in Escherichia coli
J. Bacteriol., January 15, 2002; 184(2): 363 - 369.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
G. C. Shih, C. M. Kahler, R. W. Carlson, M. M. Rahman, and D. S. Stephens
gmhX, a novel gene required for the incorporation of L-glycero-D-manno-heptose into lipooligosaccharide in Neisseria meningitidis
Microbiology, August 1, 2001; 147(8): 2367 - 2377.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
M. A. Valvano, C. L. Marolda, M. Bittner, M. Glaskin-Clay, T. L. Simon, and J. D. Klena
The rfaE Gene from Escherichia coli Encodes a Bifunctional Protein Involved in Biosynthesis of the Lipopolysaccharide Core Precursor ADP-L-glycero-D-manno-Heptose
J. Bacteriol., January 15, 2000; 182(2): 488 - 497.
[Abstract] [Full Text] [PDF]