Journal of Endotoxin Research

 

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Journal of Endotoxin Research, Vol. 4, No. 6, 463-465 (1997)
DOI: 10.1177/096805199700400611

Uridine protection against D-galactosamine-sensitized LPS lethality in mice is complete

R. Silverstein

Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas, USA

These studies show that uridine supplementation can quantitatively prevent D-galactosamine sensitization to lethal endotoxin shock. This observation serves to discount the possibility that mechanisms which do not involve uridine nucleotide depletion may contribute even marginally to the basic biochemical mechanism of D-galactosamine sensitization.


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