Journal of Endotoxin Research

 

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Journal of Endotoxin Research, Vol. 4, No. 6, 409-413 (1997)
DOI: 10.1177/096805199700400604

The dense low-density lipoprotein (LDL) subfractions are more potent than buoyant LDL for binding and neutralization of lipopolysaccharide

Mihai G. Netea

Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands

Pierre N.M. Demacker

Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands

Trees Verver-Jansen

Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands

Liesbeth Jacobs

Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands

Bart Jan Kullberg

Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands

Anton F.H. Stalenhoef

Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands

Jos W.M. Van der Meer

Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands

Lipoproteins are able to bind the lipopolysaccharide (LPS) component of Gram-negative bacteria, leading to formation of lipoprotein-LPS complexes and inhibition of endotoxin-stimulated cytokines. The differential capacity of the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subfractions to bind and neutralize LPS has been studied in 11 healthy volunteers. The dense LDL2 and LDL3 subfractions were 20-25% more potent for the inhibition of endotoxin-induced production of tumor necrosis factor (TNF) than the buoyant LDL1 subfraction (P < 0.01). This may have important consequences for the LPS-responsiveness of patients with different LDL subfraction phenotypes, and for the formation of atherogenic LDL-LPS complexes in vivo. No differences in the capacity to neutralize LPS has been detected between the various HDL subfractions.


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