Journal of Endotoxin Research

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Le Roy, D.
Right arrow Articles by Heumann, D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Le Roy, D.
Right arrow Articles by Heumann, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Endotoxin Research, Vol. 4, No. 3, 183-187 (1997)
DOI: 10.1177/096805199700400303

LPS binding protein (LBP) function in germfree mice

D. Le Roy

Division of Infectious Diseases, CHUV-Lausanne, Switzerland

M.P. Glauser

Division of Infectious Diseases, CHUV-Lausanne, Switzerland

D. Heumann

Division of Infectious Diseases, CHUV-Lausanne, Switzerland

The LPS binding protein (LBP) is an acute phase protein and an integral component of innate immunity. In normal plasma, LBP was shown to be involved in the response of monocytes to LPS. LBP was also shown to play a detrimental role in models of endotoxemia in mice. Levels of LBP increase during infection. To determine whether the presence of an intact bacterial flora is a prerequisite for normal LBP function, we analyzed the serum concentrations and functional activity of LBP in conventional and germfree mice. Baseline LBP levels were similar in both types of mice, as was the production of the pro-inflammatory cytokines TNF{alpha} and IL-6 in whole blood stimulated with LPS. Moreover, D-galactosamine sensitized germfree and conventional mice exhibited similar susceptibility to LPS. We thus conclude that the presence of a bacterial flora is not required to support normal levels and function of LBP.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. A. Dentener, A. C. E. Vreugdenhil, P. H. M. Hoet, J. H. J. Vernooy, F. H. M. Nieman, D. Heumann, Y. M. W. Janssen, W. A. Buurman, and E. F. M. Wouters
Production of the Acute-Phase Protein Lipopolysaccharide-Binding Protein by Respiratory Type II Epithelial Cells . Implications for Local Defense to Bacterial Endotoxins
Am. J. Respir. Cell Mol. Biol., August 1, 2000; 23(2): 146 - 153.
[Abstract] [Full Text]