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Effects of anti-interleukin 6 on inflammatory responses during murine septic peritonitis

Laboratory of Surgical Metabolism, Department of Surgery, Cornell University Medical College, New York, NY, USA, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

C.V. Keogh

Laboratory of Surgical Metabolism, Department of Surgery, Cornell University Medical College, New York, NY, USA

D. Helfgott

Laboratory of Surgical Metabolism, Department of Surgery, Cornell University Medical College, New York, NY, USA

L. Berman

Laboratory of Surgical Metabolism, Department of Surgery, Cornell University Medical College, New York, NY, USA

W.A. Buurman

Department of Surgery, University of Limburg, Maastricht, The Netherlands

S.F. Lowry

Laboratory of Surgical Metabolism, Department of Surgery, Cornell University Medical College, New York, NY, USA

Interleukin (IL)-6 has a limited role in the pathogenesis of the acute systemic inflammatory response syndrome elicited by bolus administration of bacteria or bacterial products. We sought to determine the role of IL-6 in septic peritonitis induced by cecal ligation and puncture (CLP). CLP led to a rapid and sustained induction of IL-6 in plasma and organ homogenates. Pretreatment (-2 h) with an anti-IL-6 mAb (1 mg) resulted in higher plasma and hepatic levels of tumor necrosis factor (TNF), as well as higher plasma concentrations of soluble TNF receptors and IL-10, while attenuating the acute phase protein response. Administration of anti-IL-6 did not influence survival. These results suggest that IL-6 production during septic peritonitis serves to inhibit the appearance of both agonist and antagonist members of the cytokine network. The importance of IL-6 in mediating the cytokine response to infection may be underestimated in more acute sepsis models.

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				L. R. Leon, A. A. White, and M. J. Kluger Role of IL-6 and TNF in thermoregulation and survival during sepsis in mice Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R269 - R277. [Abstract] [Full Text] [PDF]