Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Endotoxin Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Lanza-Jacoby, S.
Right arrow Articles by Considine, R.V.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lanza-Jacoby, S.
Right arrow Articles by Considine, R.V.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

In vitro effect of endotoxin on lipolysis and lipoprotein lipase activity in adipocytes from lean, obese and obese diabetic Zucker rats

S. Lanza-Jacoby

Departments of Surgery and Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA

G.L. Rose

Departments of Surgery and Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA

E.F. Rosato

Departments of Surgery and Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA

N. Sedkova

Departments of Surgery and Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA

R.V. Considine

Departments of Surgery and Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA

Endotoxemia and sepsis in non diabetic rats are associated with alterations in adipose tissue metabolism evidenced by an increase in lipolysis and decrease in lipoprotein lipase (LPL) activity. The purpose of this study was to determine the in vitro effect of endotoxin (LPS) on lipolysis and the activities of LPL in epididymal adipocytes isolated from 11-12-week-old obese diabetic, obese, and lean rats. Epinephrine-stimulated lipolysis was higher in the adipocytes from obese diabetic and obese rats than lean rats. Maximal lipolytic response for all groups occurred with 10-5 M of epinephrine. LPS increased the lipolytic rate in adipocytes from the obese and obese diabetic rats by 58% and 97%, respectively, in comparison to the lean rats. Heparin-releasable and extractable LPL activities were suppressed in LPS-treated adipocytes from lean rats; heparin-releasable, but not extractable LPL activity, was depressed in adipocytes from obese rats. The LPS-induced depression in LPL activities did not occur in adipocytes from obese diabetic rats. Since LPL is not altered, adipose tissue from the obese diabetic rats may not become depleted when challenged with endotoxin as is the case for the normal endotoxin-treated lean rat with diminished LPL activity.

Journal of Endotoxin Research, Vol. 2, No. 6, 449-454 (1995)
DOI: 10.1177/096805199600200608
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?