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Effect of endotoxin on cardiopulmonary function and biosynthesis of eicosanoids and TNF in calves chronically depleted of copper

Departments of Anatomy, Physiological Sciences and Radiology, North Carolina State University, Raleigh, North Carolina, USA, Microbiology, Pathology, and Parasitology, College of Veterinary Medicine and Department of Animal Science and Interdepartmental Nutrition Program, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina, USA

G.P. Gengelbach

Departments of Anatomy, Physiological Sciences and Radiology, North Carolina State University, Raleigh, North Carolina, USA, Microbiology, Pathology, and Parasitology, College of Veterinary Medicine and Department of Animal Science and Interdepartmental Nutrition Program, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina, USA

J.W. Spears

Departments of Anatomy, Physiological Sciences and Radiology, North Carolina State University, Raleigh, North Carolina, USA, Microbiology, Pathology, and Parasitology, College of Veterinary Medicine and Department of Animal Science and Interdepartmental Nutrition Program, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina, USA

L.W. Johnson

Departments of Anatomy, Physiological Sciences and Radiology, North Carolina State University, Raleigh, North Carolina, USA, Microbiology, Pathology, and Parasitology, College of Veterinary Medicine and Department of Animal Science and Interdepartmental Nutrition Program, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina, USA

P.W. Hellyer

Departments of Anatomy, Physiological Sciences and Radiology, North Carolina State University, Raleigh, North Carolina, USA, Microbiology, Pathology, and Parasitology, College of Veterinary Medicine and Department of Animal Science and Interdepartmental Nutrition Program, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina, USA

J.R. Dodam

Departments of Anatomy, Physiological Sciences and Radiology, North Carolina State University, Raleigh, North Carolina, USA, Microbiology, Pathology, and Parasitology, College of Veterinary Medicine and Department of Animal Science and Interdepartmental Nutrition Program, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina, USA

T.T. Brown, JR

Departments of Anatomy, Physiological Sciences and Radiology, North Carolina State University, Raleigh, North Carolina, USA, Microbiology, Pathology, and Parasitology, College of Veterinary Medicine and Department of Animal Science and Interdepartmental Nutrition Program, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina, USA

We evaluated the acute cardiopulmonary and biochemical (i.e. plasma concentrations of eicosanoids and serum levels of TNF) response to an infusion of Escherichia coli endotoxin (8 µg/kg i.v.) in cattle that were adequate or deficient in liver and plasma copper (Cu) concentrations. Young calves were chronically fed diets containing normal Cu (control; n = 4) and low Cu (n = 14). After ~6 months of dietary treatment, the calves were anesthetized and evaluated from 0-4 h during endotoxemia. At 0 h, plasma Cu concentrations averaged 32.4% (P < 0.05) of the control value (i.e. 0.81 ± 0.08 µg/ml). Endotoxin caused a transient, early (at 20.4 min) increase in mean pulmonary arterial pressure to 114% and 147% of baseline in normal and Cu depleted calves, respectively (P < 0.05). In Cu depleted calves, endotoxin significantly decreased heart rate (0.5-1 h) and cardiac index (0.5 h) as compared to normal calves. Endotoxin caused systemic hypotension and increased TXB2 production (at 0.5 h) and these changes were potentiated in Cu depleted calves. However, after 1 h there were no statistically significant differences between the two groups of calves for any cardiopulmonary parameter evaluated nor in plasma concentrations of eicosanoids and serum levels of TNF. We conclude that chronic dietary depletion of Cu potentiates TXB ₂ biosynthesis and worsens the acute (1 h) cardiovascular response to endotoxin challenge in cattle.

Journal of Endotoxin Research, Vol. 2, No. 6, 421-429 (1995)
DOI: 10.1177/096805199600200605


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