Innate Immunity

 

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Innate Immunity, Vol. 14, No. 3, 127-144 (2008)
DOI: 10.1177/1753425908093984

Reviews

Review: Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides

Anthony De Soyza

Transplantation and Immunobiology Group, Institute of Cellular Medicine, Newcastle University and The Freeman Hospital, Newcastle-upon-Tyne, UK, anthony.de-soyza{at}ncl.ac.uk

Alba Silipo

Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico , Napoli, Italy

Rosa Lanzetta

Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico , Napoli, Italy

John R. Govan

Cystic Fibrosis Group, Centre for Infectious Diseases, Royal Infirmary of Edinburgh, Edinburgh, UK

Antonio Molinaro

Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico , Napoli, Italy

The Burkholderia cepacia complex comprises 10 closely related Gram-negative organisms all of which appear capable of causing disease in humans. These organisms appear of particular relevance to patients with cystic fibrosis. Lipopolysaccharide (LPS) is an important virulence determinant in Gram-negative pathogens. In this review, we highlight important data within the field commenting on LPS/lipid A structure-to-function relationships and cytokine induction capacity of Burkholderia strains studied so far.

Key Words: Cystic fibrosis • Pseudomonas aeruginosa • Burkholderia cenocepacia • lipopolysaccharide • virulence


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