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Innate Immunity
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Reviews

Review: Innate immunity to tropical theileriosis

Jabbar S. Ahmed

Division of Veterinary Infection Biology and Immunology, Research Center Borstel, Borstel, Germany, jahmed{at}fz-borstel.de

Elizabeth J. Glass

Department of Genetics and Genomics, Roslin Institute and Royal (Dick) School of Veterinary Studies, Roslin Biocentre, Midlothian, UK

Diaeldin A. Salih

Division of Veterinary Infection Biology and Immunology, Research Center Borstel, Borstel, Germany

Ulrike Seitzer

Division of Veterinary Infection Biology and Immunology, Research Center Borstel, Borstel, Germany

The intracellular protozoan parasite Theileria annulata causes a severe, and often fatal, disease of pure and cross-bred cattle in tropical and subtropical countries. The present review refers to the importance of innate immunity as far as it is known to date in this infectious disease. Specifically, macrophages and the mediators produced by these cells are outlined. In addition, the latest findings concerning cattle breed differences in susceptibility to T. annulata infection in relation to macrophage activation are discussed.

Key Words: Theileria annulata • tropical theileriosis • innate immune response • resistant cattle breed

Innate Immunity, Vol. 14, No. 1, 5-12 (2008)
DOI: 10.1177/1753425907087258
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