Journal of Endotoxin Research

 

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Journal of Endotoxin Research, Vol. 13, No. 5, 251-279 (2007)
DOI: 10.1177/0968051907085986
© 2007 SAGE Publications

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Review: From therapy to experimental model: a hundred years of endotoxin administration to human subjects

Marjan Bahador

Center for Vaccine Development and Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA, mbahador{at}medicine.umaryland.edu

Alan S. Cross

Center for Vaccine Development and Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA

This article is a review of studies in which endotoxin has been administered to human subjects for experimental purposes. Data are presented in tabular form so the reader can better appreciate the objectives of individual studies. Although the original intention was to focus on the adverse events associated with these studies, unexpected serious adverse events rarely have been reported.

Key Words: Endotoxin • human subjects


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