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Journal of Endotoxin Research
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IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4

Iain MacArthur

Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada

Paul B. Mann

Department of Veterinary and Biomedical Science, The Pennsylvania State University, Pennsylvania, USA

Eric T. Harvill

Department of Veterinary and Biomedical Science, The Pennsylvania State University, Pennsylvania, USA

Andrew Preston

Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada, a.preston{at}bristol.ac.uk

The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

Key Words: Bordetella • evolution • lipid A modification • Toll-like receptor 4

Journal of Endotoxin Research, Vol. 13, No. 4, 243-247 (2007)
DOI: 10.1177/0968051907082609
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