Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Endotoxin Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Tanaka, M.
Right arrow Articles by Sakata, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tanaka, M.
Right arrow Articles by Sakata, I.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

The mRNA expression of fatty acid amide hydrolase in human whole blood correlates with sepsis

Masahiro Tanaka

Department of Emergency and Critical Care Medicine, Kinki University School of Medicine, Osakasayama, Osaka, Japan, Department of Developmental Infectious Diseases, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Osaka, Japan

Itaru Yanagihara

Department of Emergency and Critical Care Medicine, Kinki University School of Medicine, Osakasayama, Osaka, Japan, Department of Developmental Infectious Diseases, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Osaka, Japan, itaruy{at}mch.pref.osaka.jp

Hitoshi Takahashi

Department of Emergency and Critical Care Medicine, Kinki University School of Medicine, Osakasayama, Osaka, Japan

Mitsuhide Hamaguchi

Department of Emergency and Critical Care Medicine, Kinki University School of Medicine, Osakasayama, Osaka, Japan

Kumiko Nakahira

Department of Developmental Infectious Diseases, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Osaka, Japan

Ikuhiro Sakata

Department of Emergency and Critical Care Medicine, Kinki University School of Medicine, Osakasayama, Osaka, Japan

An excessive accumulation of anandamide (N-archidonoylethanolamine, AEA) is associated with septic shock. Results of previous studies have suggested that mRNA coding for the AEA degrading enzyme fatty acid amide hydrolase (FAAH), which converts AEA into arachidonic acid and ethanolamine, might be down-regulated in septic shock. We used real-time reverse transcription PCR assays to measure relative FAAH mRNA concentrations in the whole blood of 30 healthy donors and eight sepsis patients to ascertain whether such down-regulation takes place. Our results suggest that concentrations of FAAH mRNA in male and female samples from healthy donors are similar, but that concentrations are significantly lower in sepsis patients. These findings indicate that mRNA expression of FAAH in human whole blood correlates with sepsis, and may be an interesting biomarker for predicting the onset of septic shock.

Key Words: Sepsis • septic shock • fatty acid amide hydrolase • anandamide

Journal of Endotoxin Research, Vol. 13, No. 1, 35-38 (2007)
DOI: 10.1177/0968051907078607
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?