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Journal of Endotoxin Research, Vol. 13, No. 1, 15-23 (2007)
DOI: 10.1177/0968051907078605

Pretreatment of curcumin attenuates coagulopathy and renal injury in LPS-induced endotoxemia

Hsiang-Wen Chen

Department of Microbiology, Kaohsiung Medical University, Kaohsiung City, Taiwan,

Hung-Tien Kuo

Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan

Chee-Yin Chai

Department of Pathology, Kaohsiung Medical University, Kaohsiung City, Taiwan

Jian-Liang Ou

Department of Physiology, Kaohsiung Medical University, Kaohsiung City, Taiwan

Rei-Cheng Yang

Department of Physiology, Kaohsiung Medical University, Kaohsiung City, Taiwan, Department of Pediatrics, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan, hwchen{at}cc.kmu.edu.tw

Disseminated intravascular coagulation (DIC) is a lethal situation in severe infections, characterized by the systemic formation of microthrombi complicated with bleeding tendency and organ dysfunction. Current clinical trials are not promising. In this study, we investigated the protective effect of curcumin in a lipopolysaccharide (LPS)-induced DIC model in rats. Experimental DIC was induced by sustained infusion of LPS (10 mg/kg body weight) for 4 h through the tail vein. Curcumin (60 mg/kg body weight) was given intraperitoneally 3 h before LPS infusion. Results showed that, in vivo, curcumin reduced the mortality rate of LPS-infused rats by decreasing the circulating TNF-{alpha} levels and the consumption of peripheral platelets and plasma fibrinogen. Furthermore, in vivo curcumin also has the effect of preventing the formation of fibrin deposition in the glomeruli of kidney. These results reveal the therapeutic potential of curcumin in infection-related coagulopathy of DIC.

Key Words: Sepsis • TNF-{alpha} • disseminated intravascular coagulation (DIC) • fibrinogen • glomerular fibrin deposition


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