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Journal of Endotoxin Research
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Reviews

Review: Conserved and variable structural features in the lipopolysaccharide of Pseudomonas aeruginosa

Yuriy A. Knirel

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia, knirel{at}ioc.ac.ru

Olga V. Bystrova

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

Nina A. Kocharova

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

Ulrich Zähringer

Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Borstel, Germany

Gerald B. Pier

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

The review is devoted to recent progress in the structural elucidation of the lipopolysaccharide of the bacterium Pseudomonas aeruginosa, including O-antigen biological repeats, core oligosaccharide, and lipid A. Data on biosynthesis, genetics and serology of the lipopolysaccharide isolated from various P. aeruginosa O-serogroups are discussed in relation to the chemical structures.

Key Words: Lipopolysaccharide structure • core oligosaccharide • lipid A • O-antigen • serologic activity • Pseudomonas aeruginosa

Journal of Endotoxin Research, Vol. 12, No. 6, 324-336 (2006)
DOI: 10.1177/09680519060120060201
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