Journal of Endotoxin Research

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Register here to gain access to SAGE's 500+ Journals Online

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sutterwala, F. S.
Right arrow Articles by Flavell, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sutterwala, F. S.
Right arrow Articles by Flavell, R. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Endotoxin Research, Vol. 12, No. 4, 251-256 (2006)
DOI: 10.1177/09680519060120040701

NALP3: a key player in caspase-1 activation

Fayyaz S. Sutterwala

Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA

Yasunori Ogura

Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA

Dario S. Zamboni

Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Conncticut, USA

Craig R. Roy

Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Conncticut, USA

Richard A. Flavell

Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA, richard.flavell{at}yale.edu

The NLR (NACHT-LRR) family of proteins have been implicated in the regulation of immune responses and cell death pathways. Some NLR family members can form multiprotein complexes, called inflammasomes, involved in the activation of pro-inflammatory caspases. Mutations in the NALP3/CIAS1/cryopyrin gene, a member of the NLR family, are linked to three auto-inflammatory disorders: Muckle-Wells syndrome, familial cold auto-inflammatory syndrome and neonatal-onset multisystem inflammatory disease. NALP3 along with the adaptor molecule ASC activates caspase-1 in response to a wide variety of stimuli. Here we review recent findings on the biology of NALP3 suggesting that it has functions beyond that of pathogen recognition.

Key Words: Caspase-1 • innate immunity • interleukin-1ß • macrophages • NACHT-LRR (NLR)


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?