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Journal of Endotoxin Research
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Localization of the mouse defense lectin ficolin B in lysosomes of activated macrophages

Valeria L. Runza

Institute of Immunology, University of Regensburg, Regensburg, Germany

Thomas Hehlgans

Institute of Immunology, University of Regensburg, Regensburg, Germany

Bernd Echtenacher

Institute of Immunology, University of Regensburg, Regensburg, Germany

Ulrich Zähringer

Division of Immunochemistry, Research Center Borstel, Borstel, Germany

Wilhelm J. Schwaeble

Department of Infection, Immunity and Inflammation, University of Leicester, UK

Daniela N. Männel

Institute of Immunology, University of Regensburg, Regensburg, Germany, daniela.maennel{at}klinik.uni-regensburg.de

Ficolins are pattern-recognition molecules of the innate immune system able to trigger the lectin pathway of the complement activation upon binding to microbial surfaces. In humans, two plasma ficolins have been identified and characterized, whereas a third cell-associated ficolin (M-ficolin) was found on monocyte surfaces. The mouse homologue of M-ficolin is called ficolin B. Although the spatial—temporal expression patterns of mouse ficolins have been described recently, the subcellular localization of ficolin B protein is so far unknown. By using ficolin B-specific antibodies and confocal microscopy, we show that ficolin B is expressed within mouse peritoneal exudate macrophages and is co-localized with Lamp-1, a marker for lysosomes and late endosomes. In addition, the data indicate that ficolin B expression is up-regulated upon macrophage activation.

Key Words: Complement • endosomes • infection • lectin pathway

Journal of Endotoxin Research, Vol. 12, No. 2, 120-126 (2006)
DOI: 10.1177/09680519060120020801
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