Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Endotoxin Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Fernandez-Cabezudo, M. J.
Right arrow Articles by al-Ramadi, B. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fernandez-Cabezudo, M. J.
Right arrow Articles by al-Ramadi, B. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Evidence for the requirement for CD40—CD154 interactions in resistance to infections with attenuated Salmonella

Maria J. Fernandez-Cabezudo

Department of Biochemistry, UAE University, Al Ain, United Arab Emirates

Azim Ullah

Department of Medical Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates

Richard A. Flavell

Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA

Basel K. al-Ramadi

Department of Medical Microbiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates, ramadi.b{at}uaeu.ac.ae

Salmonella species include facultative intracellular pathogens which reside preferentially within cells of the host's reticulo-endothelial system. Resistance to Salmonella involves a collaboration between cells of the innate and adaptive immune systems, and protective immunity requires cell-mediated and humoral-immune responses. CD40—CD154 interactions are of central importance in the induction of cellular immune responses. In the present study, CD154-deficient (CD154—/—) mice were used to assess the role of CD40—CD154 interactions in immunity to Salmonella infection. Compared to C57BL/6 (CD154+/+) controls, CD154 —/—mice were hypersusceptible to infection by an attenuated strain of Salmonella enterica serovar Typhimurium (S. typhimurium), as evidenced by a significantly decreased survival rate. CD154—/— mice exhibited a defect in the production of IFN-{gamma} and NO in the acute phase of the disease, which resulted in a failure to control bacterial replication. We conclude that intercellular communications via the CD40—CD154 pathway play a critical role in the induction type-1 cytokine responses and protection against primary infections with attenuated Salmonella.

Key Words: Bacterial • co-stimulation • Th1/Th2 cells • cytokines • vaccination

Journal of Endotoxin Research, Vol. 11, No. 6, 395-399 (2005)
DOI: 10.1177/09680519050110060401
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?