This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Fritz, J. H. Articles by Girardin, S. E. Search for Related Content PubMed PubMed Citation Articles by Fritz, J. H. Articles by Girardin, S. E. Social Bookmarking                         What's this?

How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals

Immunité Innée et Signalisation Laboratoire, Institut Pasteur, Paris, France

Stephen E. Girardin

Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France, girardin{at}pasteur.fr

Innate immune detection of pathogens relies on specific classes of microbial sensors called pattern-recognition molecules (PRM). In mammals, such PRM include Toll-like receptors (TLRs) and the intracellular proteins NOD1 and NOD2, which belong to the family of Nod-like receptors (NLRs). Over the last decade as these molecules were discovered, a function in innate immunity has been assigned for the majority of them and, for most, the microbial motifs that these molecules detect were identified. One of the next challenges in innate immunity is to establish a better understanding of the complex interplay between signaling pathways induced simultaneously by distinct PRMs and how this affects tailoring first-line responses and the induction of adaptive immunity to a given pathogen.

Key Words: Toll-like receptors • Nod-like receptors • innate immunity

Journal of Endotoxin Research, Vol. 11, No. 6, 390-394 (2005)
DOI: 10.1177/09680519050110060301


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?