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Journal of Endotoxin Research
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Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharide

Anthony P. Moran

Department of Microbiology, National University of Ireland, Galway, Ireland, anthony.moran{at}nuigalway.ie

Wafa Khamri

Faculty of Medicine, Imperial College, St Mary's Campus, London, UK

Marjorie M. Walker

Faculty of Medicine, Imperial College, St Mary's Campus, London, UK

Mark R. Thursz

Faculty of Medicine, Imperial College, St Mary's Campus, London, UK

Surfactant protein D (SP-D) is a collagenous glycoprotein, a collectin, which functions as a pathogen-associated molecular pattern (PAMP) recognition receptor in the innate immune response. Although originally identified in the lung as a component of surfactant, SP-D also occurs in the gastric mucosa at the luminal surface and within gastric pits of mucus-secreting cells. Infection with the gastroduodenal pathogen Helicobacter pylori up-regulates expression of SP-D in human patients with gastritis, and its influence on colonization has been demonstrated in a Helicobacter SP-D-deficient (SP-D—/ —) mouse model. SP-D binds and agglutinates H. pylori cells in a lectin-specific manner, and has been shown to bind H. pylori lipopolysaccharide. Furthermore, evidence indicates that H. pylori varies LPS O-chain structure to evade SP-D binding which is speculated aids persistence of this chronic infection.

Key Words: Surfactant protein D • Helicobacter pylori • lipopolysaccharide • innate immunity • gastric mucosa • gastritis

Journal of Endotoxin Research, Vol. 11, No. 6, 357-362 (2005)
DOI: 10.1177/09680519050110061101
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