Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Endotoxin Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Stuyt, R. J.L.
Right arrow Articles by van der Meer, J. W.M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stuyt, R. J.L.
Right arrow Articles by van der Meer, J. W.M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Interleukin-18 does not modulate the acute-phase response

Rogier J.L. Stuyt

Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands

Mihai G. Netea

Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands, M.Netea{at}aig.umcn.nl

Ineke Verschueren

Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands

Charles A. Dinarello

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA

Bart Jan Kullberg

Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands

Jos W.M. van der Meer

Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands

IL-18 is a pro-inflammatory cytokine of the IL-1 family and it induces IL-1, TNF, and IL-6, all of which are endogenous pyrogens. The pyrogenic properties of recombinant IL-18 were studied in a rabbit model of fever. rIL-18 did not cause fever when injected intravenously into rabbits. Furthermore, the ability of rIL-18 to modulate other components of the acute-phase response was assessed. rIL-18 did not induce leukocytosis, or changes of circulating concentrations of lipoproteins and corticosterone in mice. In conclusion, rIL-18 is not able to induce a febrile response in rabbits and does not modulate the acute-phase response in mice.

Key Words: Acute-phase response • fever • IL-18 • IL-1

Journal of Endotoxin Research, Vol. 11, No. 2, 85-88 (2005)
DOI: 10.1177/09680519050110020301
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?