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Toll and Toll-9 in Drosophila innate immune responseProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA, Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USAProgram in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts, USA, Tony.IP{at}umassmed.edu
In both insects and mammals, members of the Toll receptor family play important roles in the initial events leading to the activation of immunity genes. The prototypic Toll in Drosophila appears to be activated by a host protein ligand after microbial stimulation. The cellular events and the biological response after Toll activation, however, require further investigation. We used transgenic Drosophila strains expressing NF-
Key Words: Drosophila • innate immunity • receptor • Toll • Toll-9
Journal of Endotoxin Research, Vol. 10, No. 4,
261-268 (2004) |
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B and Toll proteins to investigate innate immune response in whole larvae and dissected larval fat bodies. Substantial activation of antimicrobial peptide genes was observed after septic injury. To circumvent the contribution of injury-induced response, we used dissected larval fat bodies to show that commercially available microbial compounds were able to alter the cellular distribution of Toll. The results also demonstrate that complex cellular events, including receptor trafficking, likely take place after stimulation of the larval immune tissue. By genome-wide expression analysis, we further show that Toll and Toll-9 may utilize the same signaling pathway in activating many immunity genes. Thus, the innate immune response in Drosophila is regulated by complex mechanisms, which involve Toll and other Toll-related proteins.