Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Journal of Endotoxin Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Jingqing Hang
Right arrow Articles by Christiani, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jingqing Hang,
Right arrow Articles by Christiani, D. C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

TLR4 Asp299Gly and Thr399Ile polymorphisms are very rare in the Chinese population

Jingqing Hang

Shanghai Putuo District People's Hospital, Shanghai, China

Wei Zhou

Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA

Hongxi Zhang

Shanghai Putuo District People's Hospital, Shanghai, China

Bixiong Sun

Shanghai Putuo District People's Hospital, Shanghai, China

Helian Dai

Shanghai Putuo District People's Hospital, Shanghai, China

Li Su

Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA

David C. Christiani

Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA, dchris{at}hohp.harvard.edu

Endotoxin is an important component of bio-aerosols that contribute to airway inflammation and airflow obstruction. Toll-like receptor 4 (TLR4) mediates the host response to bacterial lipopolysaccharide (LPS), and the Asp299Gly and Thr399Ile polymorphisms have been associated with the development of respiratory diseases. We hypothesized that TLR4 polymorphisms may be associated with a decline of lung function in cotton workers who were exposed continuously to endotoxin. We investigated these two polymorphisms in our 20-year longitudinal cohort of Han Chinese cotton and silk textile workers. The two polymorphisms were genotyped using TaqMan and PCR-restriction fragment length polymorphism methods. No homozygous or heterozygous variant genotypes of the Asp299Gly and Thr339Ile polymorphisms were detected in 491 samples of this population. Our results suggest that the TLR4 Asp299Gly and Thr339Ile polymorphisms are very rare in the Chinese population.

Key Words: TLR4 polymorphisms • Asp299Gly • Thr399Ile • Chinese population

Journal of Endotoxin Research, Vol. 10, No. 4, 238-240 (2004)
DOI: 10.1177/09680519040100040601
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?