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Journal of Endotoxin Research, Vol. 10, No. 4, 238-240 (2004)
DOI: 10.1177/09680519040100040601
© 2004 SAGE Publications

TLR4 Asp299Gly and Thr399Ile polymorphisms are very rare in the Chinese population

Jingqing Hang

Shanghai Putuo District People's Hospital, Shanghai, China

Wei Zhou

Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA

Hongxi Zhang

Shanghai Putuo District People's Hospital, Shanghai, China

Bixiong Sun

Shanghai Putuo District People's Hospital, Shanghai, China

Helian Dai

Shanghai Putuo District People's Hospital, Shanghai, China

Li Su

Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA

David C. Christiani

Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA, dchris{at}hohp.harvard.edu

Endotoxin is an important component of bio-aerosols that contribute to airway inflammation and airflow obstruction. Toll-like receptor 4 (TLR4) mediates the host response to bacterial lipopolysaccharide (LPS), and the Asp299Gly and Thr399Ile polymorphisms have been associated with the development of respiratory diseases. We hypothesized that TLR4 polymorphisms may be associated with a decline of lung function in cotton workers who were exposed continuously to endotoxin. We investigated these two polymorphisms in our 20-year longitudinal cohort of Han Chinese cotton and silk textile workers. The two polymorphisms were genotyped using TaqMan and PCR-restriction fragment length polymorphism methods. No homozygous or heterozygous variant genotypes of the Asp299Gly and Thr339Ile polymorphisms were detected in 491 samples of this population. Our results suggest that the TLR4 Asp299Gly and Thr339Ile polymorphisms are very rare in the Chinese population.

Key Words: TLR4 polymorphisms • Asp299Gly • Thr399Ile • Chinese population


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