Journal of Endotoxin Research

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shariat-Madar, Z.
Right arrow Articles by Schmaier, A. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Endotoxin Research, Vol. 10, No. 1, 3-13 (2004)
DOI: 10.1177/09680519040100010101
© 2004 SAGE Publications

Reviews

Review: The plasma kallikrein/kinin and renin angiotensin systems in blood pressure regulation in sepsis

Zia Shariat-Madar

Departments of Internal Medicine, The University of Michigan, Ann Arbor, Michigan, USA

Alvin H. Schmaier

Departments of Internal Medicine, The University of Michigan, Ann Arbor, Michigan, USA, aschmaie{at}umich.edu, Department of Pathology, Hematology/Oncology Division, The University of Michigan, Ann Arbor, Michigan, USA

The hemodynamics of septic shock after endotoxinemiais influenced by the plasma kallikrein/kinin and the renin angiotensin systems. In recent years, new information has improved understanding of the protein/biologically active peptide interactions between these two systems. The plasma kallikrein/kinin system, more commonly known as the contact system, has undergone a re-evaluation as to how it assembles on cell membranes for physiological and pathophysiological activation and as to its role in Gram-negative sepsis. It has been proposed that it counterbalances the plasma renin angiotensin system. Furthermore, more knowledge about the renin angiotensin system has become available on how it either opposes the actions of the kallikrein/kinin system or, in some cases, summates with it. Understanding the interactions between these two systems may lead to development of better pharmacological treatments for endotoxin-induced shock.

Key Words: Kallikrein/kinin • renin • angiotensin • hemodynamics • sepsis • blood pressure


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?