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Journal of Endotoxin Research
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Characteristic biological activities of lipopolysaccharides from Sinorhizobium and Mesorhizobium

Yasuyo Tsukushi

Department of Natural Science Informatics, School of Informatics and Sciences, Nagoya University, Nagoya, Aichi, Japan, Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan

Nobuo Kido

Department of Natural Science Informatics, School of Informatics and Sciences, Nagoya University, Nagoya, Aichi, Japan

Kazuhiko Saeki

Department of Biology, Osaka University Graduate School of Science, Toyonaka, Osaka, Japan

Tsuyoshi Sugiyama

Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan

Naoki Koide

Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan

Isamu Mori

Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan

Tomoaki Yoshida

Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan

Takashi Yokochi

Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan, yokochi{at}aichi-med-u.ac.jp

The biological actions of lipopolysaccharides (LPSs) from Sinorhizobium meliloti, Mesorhizobium loti and Escherichia coli were compared. In biological activities including lethality, production of tumor necrosis factor (TNF)-{alpha} and nitric oxide (NO), adjuvant action and Limulus activity, LPS from S. meliloti exhibited stronger actions than LPS from M. loti, but had a weaker action than LPS from E. coli. On the other hand, M. loti LPS showed a higher activity to activate human complement than S. meliloti LPS. Further, there was a significant difference in polymyxin B binding between S. meliloti LPS and M. loti LPS, suggesting a difference in the lipid A structure. LPSs from S. meliloti and M. loti seem to exhibit characteristic biological actions that may be dependent on the difference in the lipid A structure.

Key Words: Rhizobium • Sinorhizobium • LPS • lipid A • Mesorhizobium

Journal of Endotoxin Research, Vol. 10, No. 1, 25-31 (2004)
DOI: 10.1177/09680519040100010301
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