This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Manthey, C.L. Articles by Vogel, S.N. Search for Related Content PubMed Articles by Manthey, C.L. Articles by Vogel, S.N. Social Bookmarking                   What's this?

Taxol: a promising endotoxin research tool

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

S.N. Vogel

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

Recently, endotoxin research has benefited from the cross fertilization of two fields of study. Investigation into the cellular actions of the anticancer drug, taxol, has suggested novel tools with which to investigate the signaling apparatus that mediates macrophage activation by bacterial lipopolysaccharide. ² In turn, this research may ultimately cause a re-examination of the belief that microtubules are the singular molecular target for taxol and suggest additional potential mechanisms for the antineoplastic actions of taxoids. The aim of this chapter is to review the actions of taxol on macrophages and the evidence that taxol engages the LPS signaling apparatus. Microtubule-independent targets for taxol are proposed, as is the use of taxol as a novel tool for endotoxin research.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				P. B. Cassidy, P. J. Moos, R. C. Kelly, and F. A. Fitzpatrick Cyclooxygenase-2 Induction by Paclitaxel, Docetaxel, and Taxane Analogues in Human Monocytes and Murine Macrophages: Structure-Activity Relationships and Their Implications Clin. Cancer Res., March 1, 2002; 8(3): 846 - 855. [Abstract] [Full Text] [PDF]

				N. Bhat, P.-Y. Perera, J. M. Carboni, J. Blanco, D. T. Golenbock, T. N. Mayadas, and S. N. Vogel Use of a Photoactivatable Taxol Analogue to Identify Unique Cellular Targets in Murine Macrophages: Identification of Murine CD18 as a Major Taxol-Binding Protein and a Role for Mac-1 in Taxol-Induced Gene Expression J. Immunol., June 15, 1999; 162(12): 7335 - 7342. [Abstract] [Full Text] [PDF]

				T. Kirikae, T. Nitta, F. Kirikae, Y. Suda, S. Kusumoto, N. Qureshi, and M. Nakano Lipopolysaccharides (LPS) of Oral Black-Pigmented Bacteria Induce Tumor Necrosis Factor Production by LPS-Refractory C3H/HeJ Macrophages in a Way Different from That of Salmonella LPS Infect. Immun., April 1, 1999; 67(4): 1736 - 1742. [Abstract] [Full Text] [PDF]

				P. J. Moos, D. T. Muskardin, and F. A. Fitzpatrick Effect of Taxol and Taxotere on Gene Expression in Macrophages: Induction of the Prostaglandin H Synthase-2 Isoenzyme J. Immunol., January 1, 1999; 162(1): 467 - 473. [Abstract] [Full Text] [PDF]

				T. M. Doherty, A. Sher, and S. N. Vogel Paclitaxel (Taxol)-Induced Killing of Leishmania major in Murine Macrophages Infect. Immun., September 1, 1998; 66(9): 4553 - 4556. [Abstract] [Full Text] [PDF]