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Journal of Endotoxin Research
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Regulation of endotoxin mitogenicity in murine spleen cells by tumor necrosis factor {alpha}

D.M. Jakobs

Forschungsinstitut Borstel, Borstel, Germany

F.U. Schade

Forschungsinstitut Borstel, Borstel, Germany

In the present study the role of tumor necrosis factor {alpha} (TNF{alpha}) in endotoxin-induced mitogenicity of mouse spleen cells was examined. TNF{alpha} was found to enhance endotoxin-induced proliferation of spleen cells. However, in the absence of endotoxin, tumor necrosis factor treatment was without effect. An antiserum against TNF{alpha} completely abolished the mitogenic effect of endotoxin in spleen cell cultures. This inhibition was reversed by exogenously added TNF{alpha}. The TNF{alpha} production in spleen cell cultures reached a maximum after 6 h. When the antiserum was added to cultures at various time intervals following endotoxin addition, maximal inhibition was observed at a time point 6 h after the start. These data suggest that TNF{alpha} has a function in endotoxin-induced mitogenicity of murine spleen cells.

Journal of Endotoxin Research, Vol. 1, No. 3, 175-179 (1994)
DOI: 10.1177/096805199400100306
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